Dizocilpine hydrogen maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate

Name	(+)-MK 801 Maleate
Synonyms	mk801 (+)MK-801 MALEATE (+)-MK 801 Maleate (-)-MK-801 MALEATE (+)-MK-801 HYDROGEN MALEATE (DIZOCILPINE MALEATE) (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate (5S,10R)-(-)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE MALEATE d)cyclohepten-5,10-imine,10,11-dihydro-5-methyl-5h-dibenzo((5s)-5h-dibenzo((z)-2-b (5S,10R)-(+)-5-Methyl-10,11-dihydro-(5H)-dibenzo[a.d]cycloheptene-5,10-iminemaleate Dizocilpine hydrogen maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
CAS	77086-22-7
EINECS	278-614-5
InChIKey	QLTXKCWMEZIHBJ-FWHYOZOBSA-N

Molecular Formula	C20H19NO4
Molar Mass	337.37
Melting Point	208.5-210°
Specific Rotation(α)	D20 +114° (c = 0.0128 g/2 ml ethanol)
Solubility	DMSO: >20mg/mL
Appearance	solid
Color	white
Storage Condition	Inert atmosphere,2-8°C
In vitro study	[MK-801 inhibition of N-methyl-D-aspartate-induced [MK-801 causes continuous, persistent blockade of NMDA-induced currents in the hippocampus. MK-801 (< 500 μm) concentration-dependently prevents LPS-induced microglial activation in Mg BV-2 cells, even MK-801 prolonged administration in the presence of NMDA, this was accompanied by an increase in Cox-2 protein expression. In BV-2 cells, MK-801 (< 500 μm) induced microglial TNF-α export with an EC50 of 400 μm.
In vivo study	Treatment of mice with MK-801 (1 mg/kg) before each METH injection reduced the extent of 55% DA depletion in the striatum of mice. In the mouse striatum, MK-801 (1 mg/kg) attenuated the effect of METH on microglia activation. In rats, cocaine-related memory reactivation in the CPP environment preceded MK-801 (0.05 mg/kg or 0.2 mg/kg, I. p.) administration attenuates subsequent cocaine-induced recovery without interference occurring in rats and without reactivation in the CPP environment. MK-801 (0.2 mg/kg, I. p.) prior to two reactivations in the cage did not inhibit subsequent cocaine-induced reconstitution.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	HP1093575

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CAS: 77086-22-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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Dizocilpine hydrogen maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate Request for Quotation